What are polynucleotides (PDRN) in skincare?

Polynucleotides, often labeled PDRN, are purified DNA fragments used in aesthetic medicine and skincare to support repair signaling, hydration behavior, and tissue quality. They are often derived from salmon DNA because it can be purified and is structurally compatible with human tissue.

Is “salmon DNA” the same as PDRN?

In most aesthetic contexts, “salmon DNA” refers to polynucleotides/PDRN derived from salmon sources. The headline is marketing; the functional concept is DNA fragments used to support regenerative signaling.

What does PDRN actually do for the skin?

PDRN is generally used to support skin quality by encouraging repair signaling, improving hydration patterns, and supporting the tissue environment. It is commonly discussed for concerns like thin-looking skin, under-eye crepiness, post-treatment recovery support, and overall resilience.

What is the difference between injectable PDRN and topical PDRN?

Injectable PDRN delivers polynucleotides directly into the skin, where they can influence tissue behavior more directly. Topical PDRN products act primarily at the surface and upper layers and may support hydration and soothing, but they do not replicate the depth or effect of injections.

Is PDRN better than hyaluronic acid?

They serve different roles. Hyaluronic acid primarily supports hydration and plumping by binding water, while PDRN is positioned as a signaling ingredient that supports repair behavior and tissue quality. One is not universally “better”—the choice depends on the skin’s needs and the treatment goal.

Can PDRN replace fillers?

PDRN is not a structural volumizer and does not replace fillers for contour or volume restoration. It is typically used to support skin quality and the tissue environment rather than to create lift or rebuild facial architecture.

Who benefits most from polynucleotides?

Polynucleotides are often chosen by people focused on tissue quality—skin that looks thin, stressed, or less resilient, areas like under-eye crepiness, and recovery support after procedures. They are less likely to produce dramatic changes in advanced laxity or significant volume loss.

Where is PDRN being oversold?

PDRN is sometimes marketed as a dramatic anti-aging solution or a filler replacement. In reality, it is best understood as a supportive regenerative tool that may improve skin behavior and resilience, not a substitute for structural correction or instant contour change.

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Melasma: Why It's the Hardest Pigmentation to Treat

Dr. Lazuk
Feb 23
2 min read

Melasma: Why It's the Hardest Pigmentation to Treat

By Dr. Lazuk, Co-Founder and CEO of Lazuk Cosmetics® | Esthetics® | Alpharetta, GA

I want to talk about the pigmentation condition that humbles even the best dermatologists.

Melasma.

Melasma is a hormonally influenced, UV-triggered deepening of pigmentation — most commonly across the cheeks, forehead, and upper lip.

What makes it so difficult?

It's not just a surface problem. In many patients, pigment sits in both the epidermis and the deeper dermis. Topical brighteners alone often can't reach all of it.

It's also hormonally driven. Which means pregnancy, oral contraceptives, and hormonal shifts can all re-trigger it — even after successful treatment.

And UV exposure of even small amounts will stimulate it. Which is why SPF is non-negotiable. Not optional. Not most days.

Every single day.

What approaches work best? A combination strategy. SPF. Tyrosinase inhibitors like kojic acid and tranexamic acid. And carefully selected in-office treatments from a provider who understands melasma's behavior.

It's a long game. But it's winnable.

May your skin glow as brightly as your smile.

~ Dr. Lazuk

CEO & Co-Founder

Dr. Lazuk Cosmetics® | Lazuk Esthetics®

Alpharetta, GA | Johns Creek, GA | Milton, GA | Suwanee, GA

Entertainment-only medical disclaimer

This content is for educational and entertainment purposes only and is not intended as medical advice. Individual skin needs vary and should be evaluated by a licensed professional.

https://www.youtube.com/watch?v=COmsn0RxDtY

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